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DNA Immunization: evaluation of genetic vaccine potential of PFR in trypanosomatidae using the leishmania model, phase 11

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dc.contributor.authorGore Saravia, Nancy
dc.date.accessioned2023-12-22T18:02:13Z
dc.date.available2023-12-22T18:02:13Z
dc.date.issued2001-08-31
dc.description1 documentospa
dc.description.abstractDuring their life cycle, Leishmania parasites multiply as flagellated promastigotes within the alimentary tract of the sand fly vector (genus Lufzomyia) and subsequently migrate anteriorly. During feeding, the sand fly transmits flagellated promastigotes to the mammalian host that enter macrophages and transform into aflagellated amastigotes. The presence of a flagellum consisting of an axonema and a lattice-like structure known as the Paraflagellar Rod (PFR), which has a role in the flagellar moti lit y of the parasite, is a distinguishing characteristic of the promastigote stage.eng
dc.format.extent22 p.
dc.format.mimetypeapplication/pdf
dc.identifier.urihttps://repositorio.minciencias.gov.co/handle/20.500.14143/50100
dc.language.isospa
dc.publisherColciencias
dc.publisherCIDEIM
dc.publisher.placeCali
dc.rights.accessrightsinfo:eu-repo/semantics/openAccess
dc.rights.creativecommonsAtribución 4.0 Internacional (CC BY 4.0)
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subject.lembVacunas
dc.subject.lembProyectos de investigación
dc.subject.proposalParásitosfra
dc.subject.proposalLeishmaniaspa
dc.subject.proposalInmunizaciónita
dc.titleDNA Immunization: evaluation of genetic vaccine potential of PFR in trypanosomatidae using the leishmania model, phase 11eng
dc.typeInforme de investigación
dc.type.coarhttp://purl.org/coar/resource_type/c_18ws
dc.type.contentText
dc.type.driverinfo:eu-repo/semantics/report
dc.type.redcolhttp://purl.org/redcol/resource_type/INF
dc.type.versioninfo:eu-repo/semantics/publishedVersion
dcterms.audienceEstudiantes, Profesores, Comunidad científica colombiana, etc.
dcterms.references• Alexander J, Stimson WH.1988. Sex hormones and the course ot parasitic infection. Parasitology Today, 4: 189-193.
dcterms.references• Giannini MSH. 1986. Sex-influenced response in the pathogenesis of cutaneous leishmaniasis in mice. Parasite Immunology, 8:31-37.
dcterms.references• Moare, L.L. , Santrich, C. and J.H. Lebowitz 1996. Stage specific express ionof the Leishmania mexicana paraflagellar rod protein PFR-2. Mol. Biochem. Parasitol. 80: 125-135.
dcterms.references• Pisetsky OS. 1996. Immune activation by bacterial ONA: a new genetic codeo Immunity. 5:303-310.
dcterms.references• Ruiz, A.M., Esteva, M. Cabeza Merkert, P., Laguens, R.P. and E.L. Segura. Protective immunity and pathology induced by inoculation of mice with different subcellular fractions of Trypanosoma cruzi. Acta Tropica 42:299-309.
dcterms.references• Segura, E.L. Paulone, J. , and J.A. Cerisola. 1976. Experimental Chagas disease protective activity in relation with subcellular fractions of the parasite. J. Parasitol.62: 131-133.
dcterms.references• Segura, E.L., Vazquez, C. Bronzina, A. Campos, J.M., Cerisola, J.A. and S.M.Cappa. 1977. Antigens of the subcellular fractions of Trypanosoma cruzi 11 :
dcterms.referencesFlagella and membrane fractions. J. ProtozooI.24:540--43.
dcterms.references• Sharifi 1, FeKri AR, Aflatonian MR, Khamesipour A, Nadim A, Mousavi MR, Momeni AZ, Oowlati Y, Godal T, Zicker F, Smith PG, Modabber F. 1998. Randomised vaccine trial of single dose ot killed Leishmania majar plus BCG 20 against anthroponotic cutaneous leishmaniasis in Sam, Iran. Lancet, 23;351 (9115): 1540-3
dcterms.references• Wrightsman, R.A. Miller, M.J., Saborio, J.L. and J.e. Manning. 1995. Pure paraflagellar rod protein protects mice against Trypanosoma cruzi infection. Infec. Immunity. 63: 122-125.
dcterms.references• Zimmerman S. , Egeter O., Hausman S, Lipford GS., Rócken M. , Wagner H. and Hegg K: 1998. Cutting edge: CpG oligodeoxynucleotides trigger protective and curative Th1 responses in lethal murine leishmaniasis. The Journal of Immunology. 160: 3627-3630.
dspace.entity.typePublication
oaire.accessrightshttp://purl.org/coar/access_right/c_abf2
oaire.awardnumber22200522499
oaire.awardtitleDNA Immunization: Evaluation of genetic vaccine potential of PFR in Trypanosomatidae using the Leishmania model, Phase 11
oaire.funderidentifier.colciencias22290522499
oaire.fundernameDepartamento Administrativo de Ciencia, Tecnología e Innovación [CO] Colciencias
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85

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