Publication:
Three practical approaches for the synthesis of novel 4,7-dihetarylpyrazolo[1,5-a] [1,3,5] triazines

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col.comunidadvinculadaComunidad científica colombianaes_CO
col.contrato0633-2009es_CO
col.date.proyecto2012
col.programa.colcienciasPrograma de ciencias básicases_CO
col.tipo.espArtículos de investigaciónes_CO
dc.audienceProfesoreses_CO
dc.audienceInvestigadoreses_CO
dc.coverage.spatialPasto, Nariñoes_CO
dc.creatorInsuasty Insuasty, Henry Edgardo
dc.creatorInsuasty Obando, Braulio Argiro
dc.creatorCastro, Edison
dc.creatorQuiroga Pueyo, Jairo
dc.creatorAbonia González, Rodrigo
dc.creatorNogueras, Manuel
dc.creatorCobo, Justo
dc.creator.corporativoUniversidad del Valle, Univallees_CO
dc.creator.corporativoUniversidad de Nariño, UDENARes_CO
dc.creator.mailhein@udenar.edu.coes_CO
dc.date.accessioned2018-09-26T20:16:06Z
dc.date.available2018-09-26T20:16:06Z
dc.date.embargoEndinfo:eu-repo/date/embargoEnd/2024-01-31es_CO
dc.date.issued2012
dc.description.abstractNovel 4,7-dihetarylpyrazolo[1,5-a][1,3,5]triazines were synthesized from three different approaches. The first one, involved a one-step reaction between 5-amino-3-hetaryl-1H-pyrazoles and O,S-diethyl hetaroylimidothiocarbonates or S,S-diethyl hetaroylimidodithiocarbonates under solvent-free conditions employing microwave irradiation as the energy source. In the second approach, conventional heating under reflux in DMF as solvent was used instead of the microwave irradiation; and the third one was achieved from a two-step sequence through the treatment of 5-amino-3-hetaryl-1H-pyrazoles with hetaroyl isothiocyanates and the subsequent S-alkylation and cyclization process in DMF as solvent. Some intermediates were isolated and characterized to support the regiochemistry of the studied reactions. The structures of the new compounds were unambiguously established by spectroscopic and analytical techniques.es_CO
dc.description.isprojectnoes_CO
dc.description.projectid1104-489-25175es_CO
dc.description.projectnameSíntesis de nuevas pirazolo[1,5-a]-1,3,5-triazinas sustituidas con fragmentos amino y anillos heterocíclicos de reconocida bioactividad, en condiciones libre de disolvente, empleando irradiación con microondases_CO
dc.description.sponsorshipDepartamento Administrativo de Ciencia, Tecnología e Innovación [CO] Colcienciases_CO
dc.formatpdfes_CO
dc.format.extent7 páginases_CO
dc.identifier.doi10.1016/j.tet.2012.09.029
dc.identifier.urihttps://repositorio.minciencias.gov.co/handle/20.500.14143/21974
dc.language.isoenges_CO
dc.relation.ispartofSíntesis de nuevas pirazolo [1,5-a] -1,3,5- triazinas sustituidas con fragmentos amino y anillos heterocíclicos de reconocida bioactividad, en condiciones libre de disolvente, empleando irradiación con microondas. La publicación completa está disponible en : <a href="http://repositorio.colciencias.gov.co:80/handle/11146/21973" target="blank">http://repositorio.colciencias.gov.co:80/handle/11146/21973</a>
dc.rightsinfo:eu-repo/semantics/embargoedAccesses_CO
dc.sourceTetrahedron 68 (2012) 9384e9390es_CO
dc.source.bibliographicCitationContiene 11 referencias bibliográficas. Véase el documento adjuntoes_CO
dc.subject.keywordPyrazolo[1,5-a][1,3,5]triazines
dc.subject.keywordO,S-Diethyl hetaroylimidothiocarbonates
dc.subject.keywordS,S-Diethyl hetaroylimidodithiocarbonates
dc.subject.keywordAmino H-pyrazoles
dc.subject.keywordPyrazolylthioureas
dc.subject.lembRadicales (química)es_CO
dc.subject.lembSíntesis (química orgánica)es_CO
dc.subject.spinesReacciones químicases_CO
dc.subject.spinesTecnología químicaes_CO
dc.subject.spinesCompuestos orgánicoses_CO
dc.subject.spinesProductos químicos orgánicoses_CO
dc.subject.spinesQuímica orgánicaes_CO
dc.subject.spinesResiduos orgánicoses_CO
dc.titleThree practical approaches for the synthesis of novel 4,7-dihetarylpyrazolo[1,5-a] [1,3,5] triazineses_CO
dc.typeArtículo científicoes_CO
dc.type.driverinfo:eu-repo/semantics/articlees_CO
dc.type.hasversioninfo:eu-repo/semantics/publishedVersiones_CO
dspace.entity.typePublication

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