Search of microbiological and immunological signatures of white plague disease in reef-building corals in the Colombian Caribbean.

Cadavid Gutierrez, Luis Fernando

Publication:
Search of microbiological and immunological signatures of white plague disease in reef-building corals in the Colombian Caribbean.

dc.contributor.author	Cadavid Gutierrez, Luis Fernando
dc.contributor.corporatename	Universidad Nacional de Colombia (Bogotá, Colombia)	spa
dc.contributor.researchgroup	COL0003937 - Ecosistemas Marinos Tropicales
dc.contributor.researchgroup	COL0006714 - Genetica Molecular
dc.contributor.researchgroup	COL0067087 - Inmunologia Evolutiva e Inmunogenetica
dc.contributor.researchgroup	COL0095089 - Comunicacion y Comunidades bacterianas
dc.coverage.projectdates	2011-2014	spa
dc.coverage.spatial	Caribe (Región) (Colombia)
dc.date.accessioned	2020-02-19T21:32:39Z
dc.date.accessioned	2020-12-18T01:31:18Z
dc.date.available	2020-02-19T21:32:39Z
dc.date.available	2020-12-18T01:31:18Z
dc.date.issued	2014-10-23
dc.description.abstract	Coral reefs posses an immense biodiversity comparable only to that of the tropical rain forest. In Colombia coral reefs occupy an area of 2.860 km2, with 99% located in the Caribbean, and they play a key role in the economy and social structure of costal communities. However, coral reefs are disappearing at an alarming pace that range from 5.5-9.2% a year in the Caribbean. Infectious diseases are thought to be the leading cause of such dramatic decline and current evidence suggests that their emergence is associated with deterioration of local and global environmental conditions. The most prevalent coral disease in the Caribbean is the White Plague Disease (WPD), affecting at least 53 species. Identification of etiological agents, however, has been problematic. This is due in part to the fact that only ~2% of bacteria can be cultured and that most coral diseases are likely to be caused by consortia of different bacteria. In addition, little is known about the factors that determine coral susceptibility or resistance to diseases. In retrospect, most efforts have failed to consider the dynamic interaction between microbial communities, the coral immune competence, and the environment. Corals are symbiotically associated to microbial communities that might change their relative densities, range, and virulence properties in response to variations in the environment or host immunity. In turn, immunity can be affected by variations in microbial communities and environmental factors. Thus, a complex network of interactions between microorganisms, the coral immune system, and the environment defines the health - disease balance. We aim to characterize the bacterial diversity associated to Montastraea sp. corals from Santa Marta Bay (Colombia) affected by WPD, as a signature of the disease and, in addition, to identify immune-related proteins differentially expressed between healthy and diseased corals as a proxy for their immune competence. The type and relative densities of bacterial communities consistently present in diseased corals will give insights into the WPD pathogenesis and will serve as a biomarker for disease progression and pathogenesis. Likewise, the characterization of the coral immune proteome will set the basis to understand the defense mechanisms of corals against diseases. The research team involved in this proposal is conformed by specialists in microbiology, genomics, proteomics, molecular biology, and comparative immunology, reflecting the interdisciplinary character of the proposal. This proposal reflects a strong integration of education with state-of-the-art research, through the formation of pre- and postgraduate students and design of new curricula. Finally, at least two publications in international journals will derived from this project, and the results will be presented in international and national scientific meetings.	spa
dc.format.extent	50 páginas.	spa
dc.identifier.instname	Colciencias	spa
dc.identifier.reponame	Repositorio Colciencias	spa
dc.identifier.repourl	http://colciencias.metabiblioteca.com.co	spa
dc.identifier.uri	https://colciencias.metadirectorio.org/handle/11146/40132
dc.language.iso	spa	spa
dc.relation.ispartofseries	informe;
dc.rights.accessrights	info:eu-repo/semantics/openAccess	spa
dc.rights.accessrights	http://purl.org/coar/access_right/c_abf2	spa
dc.rights.creativecommons	https://creativecommons.org/licenses/by/4.0/	spa
dc.subject.proposal	Coral Reefs	spa
dc.subject.proposal	Bacterial Communities	spa
dc.subject.proposal	Coral Holobiont	spa
dc.subject.proposal	Invertebrate Immunity	spa
dc.subject.proposal	White Plage Disease	spa
dc.title	Search of microbiological and immunological signatures of white plague disease in reef-building corals in the Colombian Caribbean.	spa
dc.type	Informe de investigación	spa
dc.type.coar	http://purl.org/coar/resource_type/c_18ws	spa
dc.type.content	Text	spa
dc.type.driver	info:eu-repo/semantics/report	spa
dc.type.redcol	https://purl.org/redcol/resource_type/PID	spa
dc.type.version	info:eu-repo/semantics/submittedVersion	spa
dc.type.version	http://purl.org/coar/version/c_71e4c1898caa6e32	spa
dc.type.version	info:eu-repo/semantics/submittedVersion	spa
dcterms.audience	Estudiantes, Profesores, Comunidad científica colombiana, etc.	spa
dspace.entity.type	Publication
oaire.awardnumber	110152128416	spa
oaire.funderidentifier.colciencias	322-2011-FFJC
oaire.fundername	Departamento Administrativo de Ciencia, Tecnología e Innovación [CO] Colciencias	spa
oaire.fundingstream	Programa Nacional en Ciencias del Mar y los recursos hidrobiológicos	spa
oaire.objetives	To characterize the bacterial communities associated to the reef-building coral Montastrea sp. affected with WPD in the Colombian Caribbean and to evaluate the global immune competence of the coral against the disease.	spa