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Carga de infección humana en la transmisión doméstica y pérdida de susceptibilidad a medicamentos en la Leishmaniasis cutánea.

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dc.contributor.authorRubiano, Luisa Consuelo
dc.contributor.corporatenameCentro Internacional de Entrenamiento e Investigaciones Médicas (CIDEIM) (Cali, Colombia)spa
dc.contributor.researchgroupCOL0001413 - CIDEIM
dc.coverage.spatialColombia
dc.date.accessioned2019-10-29T23:56:04Z
dc.date.accessioned2020-12-18T00:35:58Z
dc.date.available2019-10-29T23:56:04Z
dc.date.available2020-12-18T00:35:58Z
dc.date.issued2010
dc.description.abstractLa transmisión doméstica y la urbanización de la Leishmaniasis se han convertido en un fenómeno frecuente en Colombia y otros países de Latinoamérica. El desplazamiento de grupos humanos y la deforestación son factores que contribuyen. La adaptación de los vectores a hábitats alterados se evidencia por la frecuencia y presencia diseminada geográficamente de Lutzomyia dentro de las viviendas. (Apartes del texto).spa
dc.format.extent45 páginas.spa
dc.identifier.instnameColcienciasspa
dc.identifier.reponameRepositorio Colcienciasspa
dc.identifier.repourlhttp://colciencias.metabiblioteca.com.cospa
dc.identifier.urihttps://colciencias.metadirectorio.org/handle/11146/39571
dc.language.isospaspa
dc.relation.ispartofseriesInforme;
dc.rights.accessrightsinfo:eu-repo/semantics/openAccessspa
dc.rights.accessrightshttp://purl.org/coar/access_right/c_abf2spa
dc.rights.creativecommonshttps://creativecommons.org/licenses/by/4.0/spa
dc.subject.armarcLeishmaniasis
dc.subject.armarcEnfermedades transmisibles
dc.subject.armarcInsectos vectores
dc.subject.armarcLeishmaniasis mucocutánea
dc.subject.proposalCutaneous Leishmaniasisen
dc.subject.proposalDomestic Transmissionen
dc.subject.proposalHuman reservoir of infectionen
dc.subject.proposalMicrosatellite Genotypingen
dc.subject.proposalParasite Burdenen
dc.titleCarga de infección humana en la transmisión doméstica y pérdida de susceptibilidad a medicamentos en la Leishmaniasis cutánea.spa
dc.typeInforme de investigaciónspa
dc.type.coarhttp://purl.org/coar/resource_type/c_18wsspa
dc.type.contentTextspa
dc.type.driverinfo:eu-repo/semantics/reportspa
dc.type.redcolhttps://purl.org/redcol/resource_type/PIDspa
dc.type.versioninfo:eu-repo/semantics/submittedVersionspa
dc.type.versionhttp://purl.org/coar/version/c_71e4c1898caa6e32spa
dc.type.versioninfo:eu-repo/semantics/submittedVersionspa
dcterms.audienceEstudiantes, Profesores, Comunidad científica colombiana, etc.spa
dspace.entity.typePublication
oaire.awardnumber222951928948spa
oaire.funderidentifier.colciencias252-2010
oaire.fundernameDepartamento Administrativo de Ciencia, Tecnología e Innovación [CO] Colcienciasspa
oaire.fundingstreamPrograma Nacional de CTeI en Saludspa
oaire.objetivesProject Goal: To obtain the evidence base to prevent domestic transmission of dermal leishmaniasis and preserve the useful life of first line drugs by defining the burden of Leishmania infection (symptomatic and asymptomatic) in domestically exposed populations and the role of this reservoir of human infection in transmission, and the development and dissemination of drug resistance.en
oaire.objetivesSpecific Aims : Aim 1. To determine the age-specific prevalence of parasites in blood, mucosa and dermal aspirates of the inhabitants of foci of domestic transmission of leishmaniasis. Research Questions ' What is the prevalence and relative burden of Leishmania in extralesional tissues of symptomatic and asymptomatic populations experiencing domestic transmission of dermal leishmaniasis? ' Is there an age, gender or clinical status bias in the prevalence and burden of parasites indicating that some individuals may be contributing more to transmission? Indicators ' Age specific prevalence of parasites in tissues of clinically apparent and subclinical infection established ' Individuals with high parasite burden identified Implementable outcomes 1. Magnitude of human reservoir of Leishmania infection in setting of domestic transmission estimated. 2. Quantitative reference point for assessment of subsequent interventions to reduce the burden of human infection determined. 3. Target populations for host directed interventions identified.en
oaire.objetivesSpecific Aims : Aim 2. To discern the relationship between immunological evidence of infection (DTH response to intradermal application of Leishmania antigen-leishmanin) and the presence of parasites in host tissues (blood, mucosa and healthy skin). Research Questions ' Is skin test response correlated with the detectable presence of parasites in tissues? ' Can subclinical infection in the community be parasitologically established using molecular methods? Indicators ' Relationship between skin test response and persistence of parasites established. ' Capacity of molecular amplification of Leishmania DNA to parasitologically detect subclinical infection determined. Implementable outcome 1. A gene-based tool to parasitologically detect asymptomatic infection.en
oaire.objetivesSpecific Aims : Aim 3. To determine the diversity and interrelationship of Leishmania populations circulating among the inhabitants of a focus of domestic transmission. Research Questions ' Are multiple populations of Leishmania distinguishable in domestic settings of transmission? ' Can the epidemiologic relationship of human infection with domestic transmission be discerned using phenotypic and genotypic markers? Indicators ' Diversity/similarity of Leishmania populations in representative settings of domestic transmission determined. ' Potential of phenotypic and genetic markers to discern epidemiologic relationships in the domestic setting defined. Implementable outcomes 1. Novel epidemiologic tools based on genotypic and functional markers 2. Genetic and phenotypic evidence of common or diverse sources of infection in the human population.en
oaire.objetivesSpecific Aims : Aim 4. To define the drug susceptibility and persistence of parasites isolated from lesions and extralesional tissues before and after treatment. Research Questions ' Are parasites in blood, mucosa or healthy skin sites of treated patients less susceptible to the drug used to treat patients in the community? ' Is the parasite burden or drug susceptibility of recovered parasites correlated with the clinical response to treatment? Indicators ' In vitro drug susceptibility of parasites that disseminate to extralesional tissues and persist following treatment determined. ' Prevalence and relative burden of Leishmania in extralesional tissues following treatment established. Implementable outcomes 1. Recognition of treatment as a potential control measure for transmission 2. Evidence base to compel the use of combined therapies (co-adjuvant immunotherapy and/or antileishmanial drug combinations) to minimize burden of infection in human p.en

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