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Determination of common HIV-1 cytotoxic T lymphocytes epitopes across different ethnicities for their potencial use as immunological therapy in Colombia.

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dc.contributor.authorRúgueles López, María Teresa
dc.contributor.corporatenameUniversidad de Antioquia (UDEA) (Medellín, Colombia)spa
dc.contributor.researchgroupCOL0012444 - Grupo Inmunovirologíaspa
dc.coverage.projectdates2007-2011spa
dc.coverage.spatialMedellín (Antioquia, Colombia)
dc.date.accessioned2021-09-16T13:33:45Z
dc.date.available2021-09-16T13:33:45Z
dc.date.issued2011-10-13
dc.description.abstractCytotoxic T lymphocytes (CTL) recognition of antigenic peptides (epitopes) presented by HLA class I molecules is critical for the immunity against HIV infection. The identification of CTL epitopes against HIV is complicated by several factors. 1) limited knowledge about the mechanisms involved in the generation of CTL epitopes; 2) more than 1,700 different HLA-I molecules described to date, each one capable of presenting different CTL epitopes; 3) variable distribution of HLA genes in different ethnicities making impossible to identify common CTL epitopes for all patients of a single nationality. The problem of variable distribution of HLA genes for CTL identification is particularly critical in Colombia, given the wide distribution of HIV infection among several ethnicities, including 70% Caucasoids, 15% Amerindians and 15% African descendents. The specific hypothesis of this project is that several HLA class I molecules, classified in groups known as HLA supertypes, can bind large overlapping sets of peptides from HIV and that the identification of common CTL epitopes could be used for immunological therapy against HIV in patients from all ethnicities found in Colombia.
dc.description.notesTextos en Español.
dc.format.extent130 páginas.spa
dc.format.mimetypeapplication/pdfspa
dc.identifier.urihttps://repositorio.minciencias.gov.co/handle/20.500.14143/40203
dc.language.isoengspa
dc.publisherUniversidad de Antioquiaspa
dc.publisher.placeMedellín: Universidad de Antioquia, 2021spa
dc.rightsDerechos Reservados - Universidad de Antioquia, 2021
dc.rights.accessrightsinfo:eu-repo/semantics/openAccessspa
dc.rights.creativecommonsAtribución-NoComercial-SinDerivadas 4.0 Internacional (CC BY-NC-ND 4.0)spa
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/spa
dc.subject.proposalHIV
dc.subject.proposalHLA
dc.subject.proposalCytotoxic T lymphocytes -CTL-
dc.subject.proposalSupertypes
dc.titleDetermination of common HIV-1 cytotoxic T lymphocytes epitopes across different ethnicities for their potencial use as immunological therapy in Colombia.
dc.typeInforme de investigaciónspa
dc.type.coarhttp://purl.org/coar/resource_type/c_18wsspa
dc.type.contentTextspa
dc.type.driverinfo:eu-repo/semantics/workingPaperspa
dc.type.redcolhttps://purl.org/redcol/resource_type/INFspa
dc.type.versioninfo:eu-repo/semantics/publishedVersionspa
dcterms.audienceEstudiantes, Profesores, Comunidad científica colombiana, etc.
dspace.entity.typePublication
oaire.accessrightshttp://purl.org/coar/access_right/c_abf2spa
oaire.awardnumber111540820498spa
oaire.funderidentifier.colciencias246-2007
oaire.fundernameDepartamento Administrativo de Ciencia, Tecnología e Innovación [CO] Colcienciasspa
oaire.fundingstreamPrograma Nacional de CTeI en Saludspa
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85spa

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