Browsing by Author "Pineda, Juan D."

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    Evolutionary and sequence-based relationships in bacterial AdoMet-dependent non-coding RNA methyltransferases
    (2014) Benítez Páez, Alfonso; Mosquera Rendón, Jeanneth; Cárdenas Brito, Sonia; Pineda, Juan D.; Corredor Rodríguez, Mauricio
    RNA post-transcriptional modification is an exciting field of research that has evidenced this editing process as a sophisticated epigenetic mechanism to fine tune the ribosome function and to control gene expression. Although tRNA modifications seem to be more relevant for the ribosome function and cell physiology as a whole, some rRNA modifications have also been seen to play pivotal roles, essentially those located in central ribosome region. RNA methylation at nucleobases and ribose moieties of nucleotides appear to frequently modulate its chemistry and structure. RNA methyltransferases comprise a superfamily of highly specialized enzymes that accomplish a wide variety of modifications. These enzymes exhibit a poor degree of sequence similarity in spite of using a common reaction cofactor and modifying the same substrate type.